PT-141 (Bremelanotide) is a synthetic peptide used to treat certain forms of sexual dysfunction by increasing sexual desire and arousal, acting directly on the brain.

Key Features:

• Mechanism of Action: Unlike traditional medications for erectile dysfunction (which focus on blood flow), PT-141 is a melanocortin receptor agonist. It works by stimulating specific receptors (MC3R and MC4R) in the central nervous system, particularly the hypothalamus, which modulates sexual desire, arousal, and satisfaction.

Often used for the treatment of Hypoactive Sexual Desire Disorder (HSDD) in premenopausal women. HSDD is characterised by a persistent lack of sexual desire that causes distress.

It is also widely used off-label in men to address Erectile Dysfunction (ED) and low libido, particularly for those who do not respond well to traditional blood-flow-enhancing medications like PDE5 inhibitors (e.g., Viagra or Cialis)